vorinostat (Zolinza, SAHA)
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Indications
- advanced skin cancer
- cutaneous T-cell lymphoma[4]
- stage 3 or 4 mycoses fungoides[5]
Dosage
oral
Mechanism of action
- histone deacetylase inhibitor; inhibits HDAC2
- enhances memory in mice[2]
More general terms
References
- ↑ Prescriber's Letter 14(2): 2007 New drugs approved by the FDA in 2006 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=2302213&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 2.0 2.1 Guan J-S et al. HDAC2 negatively regulates memory formation and synaptic plasticity Nature 2009 May 7; 459:55. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19424149
- ↑ Graff J et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 2012 Mar 8; 483:222 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22388814
- ↑ 4.0 4.1 Deprecated Reference
- ↑ 5.0 5.1 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015