transcription factor E2F3 (E2F-3, E2F3, KIAA0075)

Function

• transcription activator
• binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication
• the DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase
• E2F3 binds specifically to RB1 protein (cell-cycle dependent)
• component of the DRTF1/E2F transcription factor complex
• binds cooperatively with DP-1 to E2F sites
• interacts with retinoblastoma protein RB1 & related proteins (such as RBL1) that inhibit the E2F transactivation domain
• binds EAPP

Structure

• DNA-binding-domain in the central part of the molecule
• C-terminal Rb-binding domain
• belongs to the E2F/DP family

Compartment

nucleus

More general terms

• E2F

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1871
• OMIM: https://mirror.omim.org/entry/600427
• UniProt: http://www.uniprot.org/uniprot/O00716.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1871