E2F-associated phosphoprotein (EAPP) (EAPP, C14orf11, BM-036)

Function

• role in the fine-tuning of both major E2F1 activities, regulation of the cell-cycle & induction of apoptosis
• promotes S-phase entry, & inhibits p14(ARP) expression
• interacts with E2F1
• C-terminal half binds the N-terminal of E2F1
• interacts with E2F2 & E2F3, but not E2F4
• phosphorylated

Compartment

cytoplasm, nucleus

Expression

• ubiquitously expressed
• expressed in heart, placenta, skeletal muscle & pancreas > brain, lung & kidney
• in the brain, expressed in all regions with high levels in cerebellum & cerebral cortex
• expressed in COS1 & transformed skin fibroblasts
• during the cell cycle, expression disappears during mitosis

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q56P03.html