homeobox protein HOX-A9; Hox-1G (HOXA9, HOX1G)

Function

• sequence-specific transcription factor
• part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Structure

• belongs to the Abd-B homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Pathology

• chromosomal translocation t(7;11)(p15;p15) involving HOXA9 with NUP98 is found in a form of acute myeloid leukemia
• chromosomal translocation t(7;17)(p15;q23) involving HOXA9 with MSI2 may contribute to disease progression in chronic myeloid leukemia

More general terms

• homeobox protein

Database

• UniProt: http://www.uniprot.org/uniprot/P31269.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3205
• OMIM: https://mirror.omim.org/entry/142956
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3205