CD103 (integrin alpha-E, mucosal lymphocyte-1 antigen, HML-1 antigen, human mucosal lymphocyte antigen 1 antigen, ITGAE)

Function

• associates with integrin beta-7 (integrin alpha-E/beta-7)

Structure

• composed of an heavy & a light chains linked by a disulfide bond
• the integrin I-domain (insert) is a VWFA domain
• integrins with I-domains do not undergo protease cleavage
• belongs to the integrin alpha chain family
• contains 5 FG-GAP repeats
• contains 1 VWFA domain

Compartment

membrane

Expression

• expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells

Pathology

• hairy cell leukemia
• AML
• enteropathy-associated T cell lymphomas
• adult HTLV-1 associated T cell leukemia

More general terms

• integrin-alpha
• glycoprotein
• CD antigen

Component of

• integrin alpha-E/beta-7

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3682
• OMIM: https://mirror.omim.org/entry/604682
• UniProt: http://www.uniprot.org/uniprot/P38570.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3682