enhancer of mRNA-decapping protein 4 (human enhancer of decapping large subunit, Hedls, autoantigen Ge-1, autoantigen RCD-8, EDC4, HEDLS)

Function

• role in mRNA degradation
• role in mRNA decapping
• component of a mRNA decapping complex which functions in decapping of ARE-containing mRNAs
• promotes complex formation between DCP1A & DCP2
• enhances catalytic activity of DCP2 (in vitro)
• component of a complex consisting of DCP1B, EDC3, EDC4 & DDX6 (not clear if different from mRNA decapping complex)
• interacts with DCP2
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

contains 4 WD repeats

Alternative splicing

named isoforms=2

More general terms

• protein subunit
• WD repeat protein family
• phosphoprotein

Component of

• mRNA decapping complex

Database

• OMIM: https://mirror.omim.org/entry/606030
• UniProt: http://www.uniprot.org/uniprot/Q6P2E9.html