DEAD box protein 6; ATP-dependent RNA helicase p54; RCK protooncogene protein (DDX6)

Function

• RNA helicase
• mRNA degradation
• mRNA decapping
• forms a complex with DCP1A, DCP2, YJDC & RCD8
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the DEAD box helicase family, DDX6/DHH1 subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

cytoplasm, processing bodies

Expression

abundantly expressed in most tissues

Pathology

• chromosomal aberration involving DDX6 may be a cause of B-cell lymphomas, t(11;14)(q23;q32)

More general terms

• DEAD box ATP-dependent helicase

Database

• UniProt: http://www.uniprot.org/uniprot/P26196.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1656
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1656
• OMIM: https://mirror.omim.org/entry/600326