mRNA decapping enzyme 1B (DCP1B)

Function

• degradation of mRNAs
  • normal mRNA turnover
  • nonsense-mediated mRNA decay
• removes the 7-methyl guanine cap structure from mRNA, yields 5'-phosphorylated mRNA fragment & 7m-GDP
• transactivation of target genes after stimulation by TGFB1
• binds DCP1A
• part of a complex containing enzymes involved in mRNA decay, including DCP2, LSM1, LSM3 & CNOT6

Structure

belongs to the DCP1 family

Compartment

cytoplasmic, in discrete foci

More general terms

• mRNA decapping enzyme
• phosphoprotein

Component of

• mRNA decay complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=196513
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:196513
• OMIM: https://mirror.omim.org/entry/609843
• UniProt: http://www.uniprot.org/uniprot/Q8IZD4.html