U6 snRNA-associated Sm-like protein LSm1; cancer-associated Sm-like; small nuclear ribonuclear CaSm (LSM1, CASM)

Function

• plays a role in replication-dependent histone mRNA degradation
• binds specifically to the 3'-terminal U-tract of U6 snRNA
• interacts with SLBP
• interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase
• LSm subunits form a heteromer with a donut shape

Structure

belongs to the snRNP Sm proteins family

Compartment

nucleus (putative)

Pathology

• elevated expression in pancreatic cancer & in several cancer-derived cell lines

More general terms

• hnRNP-associated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27257
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27257
• OMIM: https://mirror.omim.org/entry/607281
• UniProt: http://www.uniprot.org/uniprot/O15116.html