coronin-7; Crn7; 70 kD WD repeat tumor rejection antigen homolog (CORO7)

Function

• may play a role in the maintenance of Golgi morphology & in protein export from the Golgi
• membrane-associated form is phosphorylated on Tyr (putative)
• interacts with clathrin adapter AP1 complex; interaction on Golgi membranes & not AP1-positive endosomal membranes

Structure

• belongs to the WD repeat coronin family
• contains 8 WD repeats

Compartment

• cytoplasm, cytosol (putative)
• Golgi membrane
• cytoplasmic vesicle (putative)
• predominantly cytosolic
• detected on vesicle-like cytoplasmic structures & on the cis-Golgi
• not associated with actin filaments

Alternative splicing

named isoforms=2

More general terms

• WD repeat protein family
• phosphoprotein

Additional terms

• Gt-protein or transducin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79585
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79585
• OMIM: https://mirror.omim.org/entry/611668
• UniProt: http://www.uniprot.org/uniprot/P57737.html