serine-threonine kinase receptor-associated protein; MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD (STRAP, MAWD, UNRIP)

Function

• conponent of the core SMN complex
• the SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm & is required for pre-mRNA splicing in the nucleus
• STRAP may play a role in the cellular distribution of the SMN complex
• associates with the SMN complex in the cytoplasm but not in the nucleus
• also interacts with CSDE1/UNR & MAWBP
• associates with TGF-beta receptor 1 & TGF-beta receptor 2
• shows smad7 synergistic inhibition of TGF-beta signaling

Structure

• belongs to the WD repeat STRAP family
• contains 7 WD repeats

Compartment

• cytoplasm, nucleus
• localized predominantly in the cytoplasm but also found in the nucleus

More general terms

• WD repeat protein family
• phosphoprotein

Component of

• SMN complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11171
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11171
• OMIM: https://mirror.omim.org/entry/605986
• UniProt: http://www.uniprot.org/uniprot/Q9Y3F4.html