WD repeat-containing protein 34 (WDR34)

Function

• acts as a negative regulator of the Toll-like & IL-1R receptor signaling pathways
• inhibits the MAP3K7-induced NF-kappa-B activation pathway
• inhibits MAP3K7 phosphorylation at Thr-184 & Thr-187 upon Il-1 beta stimulation
• interacts (via the WD domains) with MAP3K7 & TAB3
• interacts (via WD domains) with TAB2 (via C-terminus)
• interacts (via WD domains) with TRAF6 (via TRAF-type domains)

Structure

contains 5 WD repeats

Compartment

cytoplasm

Expression

• expressed in several cell lines (at protein level)

More general terms

• WD repeat protein family

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=89891
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:89891
• OMIM: https://mirror.omim.org/entry/613363
• UniProt: http://www.uniprot.org/uniprot/Q96EX3.html