mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3, NF-kappa-B-activating protein 1, MAP3K7IP3, TAB3)

Function

• adapter protein
• links MAP3K7 & TRAF6 or TRAF2
• mediates MAP3K7 activation in IL1 & TNF signaling
• activation of NF-kappa-B, AP1
• isoform 2 may be an oncogenic factor
• interacts with TAB1, TAB2, MAP3K7, TRAF2, TRAF6
• phosphorylated
• ubiquitinated following IL1 stimulation or TRAF6 overexpression

Alternative splicing

named isoforms=2

Expression

• widely expressed
• constitutively overexpressed in certain tumor tissues

More general terms

• MAP3K7 interacting protein
• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/300480
• UniProt: http://www.uniprot.org/uniprot/Q8N5C8.html