denticleless protein homolog (Lethal(2) denticleless protein homolog, Ddb1- & Cul4-associated factor 2, retinoic-acid regulated nuclear matrix-associated protein, DTL, CDT2, CDW1, DCAF2, L2DTL, RAMP)
Jump to navigation
Jump to search
Function
- required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase
- role in cell cycle regulation of DNA replication (putative)
- substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
- probable part of a cullin-RING E3 protein ligase complex
- interacts with CUL4B & DDB1
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure
- belongs to the WD repeat cdt2 family.
- contains 7 WD repeats
Compartment
- nucleus, nucleoplasmic side, cytoplasm
- nuclear matrix-associated
- translocates from interphase nucleus to the metaphase cytoplasm during mitosis
Alternative splicing
named isoforms=2
Expression
- expressed in placenta & testis
- very low expression in skeletal muscle
- detected in all hematopoietic tissues examined
- highest expression in thymus & bone marrow
- low level detected in the spleen & lymph node
- barely detectable level in the peripheral leukocyte
- retinoic acid down-regulates expression in NT2 cells
- expressed in all fetal tissues examined, including brain, lung, liver, & kidney
Pathology
- role in cell proliferation of NT2 embryonal carcinoma cells