WD repeat protein 79; telomerase Cajal body protein 1; WD40 repeat-containing protein encoding RNA antisense to p53 (WRAP53 TCAB1 WDR79)

Function

• phosphorylated upon DNA damage, probably by ATM or ATR
• component of the telomerase holoenzyme complex
  • controls telomerase localization to Cajal body
  • required for delivery of TERC to telomeres during S phase & for telomerase activity
• binds small Cajal body RNAs (scaRNAs)
• the mRNA encoding this protein plays a role in regulation of p53 expression at the post-transcriptional level
  • it is involved both in maintaining basal p53 mRNA levels & in p53 induction upon DNA damage
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

contains 6 WD repeats

Compartment

nucleus, Cajal body. cytoplasm

Expression

• expressed in all tissues & cell lines examined

Pathology

• defects in WRAP53 are the cause of autosomal recessive dyskeratosis congenita type 3

More general terms

• WD repeat protein family
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55135
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55135
• OMIM: https://mirror.omim.org/entry/612661
• OMIM: https://mirror.omim.org/entry/613988
• UniProt: http://www.uniprot.org/uniprot/Q9BUR4.html