factor associated with neutral sphingomyelinase activation; protein FAN; factor associated with N-smase activation (NSMAF, FAN)

Function

• couples p55 TNF-receptor neutral sphingomyelinase
• binds to neutral sphingomyelinase activation domain of p55 TNF-receptor
• regulation of ceramide production by neutral sphingomyelinase

Structure

• contains 1 BEACH domain
• contains 1 GRAM domain
• contains 6 WD repeats

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• WD repeat protein family

Additional terms

• sphingomyelinase, sphinogomyelin phosphodiesterase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8439
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8439
• OMIM: https://mirror.omim.org/entry/603043
• UniProt: http://www.uniprot.org/uniprot/Q92636.html