sphingomyelin phosphodiesterase 2; lyso-platelet-activating factor-phospholipase C; lyso-PAF-PLC; neutral sphingomyelinase; sphingomyelinase-2; N-smase; nsmase (SMPD2)

Function

• converts sphingomyelin to ceramide
• hydrolyzes 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) & 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor)
• the physiological substrate seems to be lyso-PAF

sphingomyelin + H2O = N-acylsphingosine + choline phosphate

Cofactor: Mg+2

Kinetic parameters:

• pH dependence: optimum pH is 6.5-7.5

Structure

belongs to the neutral sphingomyelinase family

Compartment

membrane

More general terms

• sphingomyelinase, sphinogomyelin phosphodiesterase
• transmembrane 2 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6610
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6610
• OMIM: https://mirror.omim.org/entry/603498
• UniProt: http://www.uniprot.org/uniprot/O60906.html