platelet-activating factor (PAF)

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Introduction

Platelet activating factor (PAF) causes increased vascular permeability, neutrophil aggregation & activation, & platelet activation at low concentrations. At high concentrations, PAF induces vasoconstriction & bronchoconstriction.

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References

  1. Barnes PJ. Molecular biology. Inflammatory activities. Nature. 1991 Jan 24;349(6307):284-5. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1846227
  2. Honda Z, Nakamura M, Miki I, Minami M, Watanabe T, Seyama Y, Okado H, Toh H, Ito K, Miyamoto T, et al. Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature. 1991 Jan 24;349(6307):342-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1846231
  3. Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 58

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