NEDD1 protein; neural cell expressed developmentally down-regulated protein 1; NEDD-1 (NEDD1)

Function

• embryonic development & differentiation of the central nervous system
• required for progression of mitosis
• promotes nucleation of microtubules from the spindle during mitosis
• prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 & Ser-637
• phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, a step in spindle formation
• interacts with FAM29A & gamma-tubulin

Structure

contains 8 WD repeats

Compartment

cytoplasm, cytoskeleton, centrosome

Alternative splicing

named isoforms=2

More general terms

• WD repeat protein family
• phosphoprotein

Additional terms

• neural precursor cell expressed developmentally downregulated (NEDD) protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=121441
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:121441
• OMIM: https://mirror.omim.org/entry/600372
• UniProt: http://www.uniprot.org/uniprot/Q8NHV4.html