WD repeat protein 48 (WD repeat endosomal protein, p80, WDR48, KIAA1449)

Function

• role in vesicular transport or membrane fusion events necessary for transport to lysosomes
• C-terminal region mediates lysosomal localization

Compartment

lysosome

Alternative splicing

named isoforms=2

Expression

ubiquitous

Pathology

• induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP)
• subsequently TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR
• may play role in generation of enlarged endosomal vesicles via interaction with TIP

More general terms

• WD repeat protein family

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TAF3.html