WD repeat protein 71 (proteasomal ATPase-associated factor 1, protein G-16, WDR71, PAAF1)

Function

• inhibits proteasome 26S assembly & proteolyticactivity by impairing association of the 19S regulatory complex with the 20S core
• interacts with PSMC1, PSMC2, PSMC3, PSMC4, PSMC5, PSMC6

Structure

contains 5 WD repeats

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed
• highest levels in kidney, brain & testis

Pathology

• in case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S
• this presumably promotes provirus transcription efficiency
• interacts with HIV-1 Tat.

More general terms

• WD repeat protein family

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BRP4.html