TAT-binding protein-1; 26S protease regulatory subunit 6A; proteasome subunit P50 (TBP1, PSMC3)

Function

• regulatory ATPase of 26S proteasome
• confers ATP dependency & substrate specificity to the 26S proteasome
• may form a heterodimer with a related family member
• interacts with PAAF1
• interacts with HIV-1 Tat, suppresses Tat-mediated transactivation

Structure

belongs to the AAA ATPase family

Compartment

cytoplasm, nucleus

More general terms

• adenosine triphosphatase (ATPase)
• transcription factor (TF)
• phosphoprotein

Component of

• 26S proteasome

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5702
• OMIM: https://mirror.omim.org/entry/186852
• UniProt: http://www.uniprot.org/uniprot/P17980.html