mitotic checkpoint protein BUB3 (budding inhibitied by benzimidazoles, BUB3)

Function

• has a dual function in spindle-assembly checkpoint signaling & in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments
• promotes the formation of stable end-on bipolar attachments
• necessary for kinetochore localization of BUB1
• regulates chromosome segregation during oocyte meiosis
• component of the BUB1/BUB3 complex
• interacts with BUB1 & BUBR1

Structure

• belongs to the WD repeat BUB3 family
• contains 5 WD repeats

Compartment

nucleus

• kinetochore (putative)
• tarts to localize at kinetochores in prometaphase 1 stage & maintains the localization until the metaphase 1 - anaphase 1 transition (putative)

Alternative splicing

named isoforms=2

More general terms

• nuclear protein
• phosphoprotein
• WD repeat protein family

Component of

• BUB1/BUB3 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9184
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9184
• OMIM: https://mirror.omim.org/entry/603719
• UniProt: http://www.uniprot.org/uniprot/O43684.html