autophagy protein 16-like; autophagy-related protein 16-1; APG16-like 1 (ATG16L1, APG16L, UNQ9393/PRO34307)

Function

• role in autophagy (putative)
• interacts with ATG5
• part of either minor or major complexes composed of
  • 4 sets of ATG12-ATG5 & ATG16L1 (400 kDa) or
  • 8 sets of ATG12-ATG5 & ATG16L1 (800 kDa) (putative)

Structure

• homooligomer
• belongs to the WD repeat ATG16 family
• contains 7 WD repeats

Compartment

• cytoplasm (putative)
• preautophagosomal structure membrane
• peripheral membrane (putative)
• localized to preautophagosomal structure where it is involved in the membrane targeting of ATG5 (putative)

Alternative splicing

• named isoforms=5
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Polymorphism

• genetic variations in ATG16L1 are associated with susceptibility to inflammatory bowel disease type 10 (phenotypically Crohn's disease)

More general terms

• autophagy protein (autophagy-related protein)
• WD repeat protein family
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55054
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55054
• OMIM: https://mirror.omim.org/entry/610767
• OMIM: https://mirror.omim.org/entry/611081
• UniProt: http://www.uniprot.org/uniprot/Q676U5.html