autophagy protein 5; APG5-like; apoptosis-specific protein (ATG5, APG5L, ASP)

Function

• required for autophagy
• conjugates to ATG12 & associates with isolation membrane to form cup-shaped isolation membrane & autophagosome
• the conjugate detaches from the membrane immediately before or after autophagosome formation is completed (putative)
• may play a role in the apoptotic process, possibly within the modified cytoskeleton
• its expression is a relatively late event in apoptosis, occurring downstream of caspase activity
• conjugated to ATG12, essential for autophagy, but not required for association with isolation membrane

Structure

belongs to the ATG5 family

Compartment

cytoplasm, colocalizes with nonmuscle actin

Alternative splicing

named isoforms=2; long, short

Expression

• ubiquitous
• the mRNA is present at similar levels in viable & apoptotic cells, whereas the protein is highly expressed in apoptotic cells
• induced by apoptotic stimuli

More general terms

• pro apoptotic protein

Additional terms

• apoptosis

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9474
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9474
• OMIM: https://mirror.omim.org/entry/604261
• UniProt: http://www.uniprot.org/uniprot/Q9H1Y0.html