WD repeat-containing protein 85; diphthamide biosynthesis protein 7 (DPH7, C9orf112, WDR85)

Function

• role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP- ribosylated by diphtheria toxin & by Pseudomonas exotoxin A
• may have a regulatory role, promoting dissociation of diphthine synthase DPH5 from elongation factor 2
• protein modification; peptidyl-diphthamide biosynthesis

Structure

• belongs to the DPH7 family
• contains 3 WD repeats

More general terms

• WD repeat protein family

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=92715
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:92715
• OMIM: https://mirror.omim.org/entry/613210
• UniProt: http://www.uniprot.org/uniprot/Q9BTV6.html