diphthine synthase (iphthamide biosynthesis methyltransferase, DPH5)

Function

• required for the methylation step in diphthamide biosynthesis (putative)
• diphthamide biosynthesis, 2nd step

S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine <--> S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine

Structure

belongs to the diphthine synthase family

Alternative splicing

named isoforms=5

More general terms

• methyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H2P9.html