WD repeat-containing protein 36; T-cell activation WD repeat-containing protein; TA-WDRP (WDR36)

Function

• role in T cell activation
• highly co-regulated with IL2

Structure

contains 9 WD repeats

Expression

• expressed in heart, placenta, liver, skeletal muscle, kidney & pancreas
• in ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina & optic nerve

Pathology

• defects in WDR36 are the cause of primary open angle glaucoma type 1G

More general terms

• WD repeat protein family

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=134430
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:134430
• OMIM: https://mirror.omim.org/entry/609669
• OMIM: https://mirror.omim.org/entry/609887
• UniProt: http://www.uniprot.org/uniprot/Q8NI36.html