telomerase protein component 1 (TEP1, p240, p80 telomerase homolog)

Function

• component of the telomerase ribonucleoprotein complex
• also component of the ribonucleoprotein vaults particle
• binds to telomerase RNA template
• binds to VAULTRC1, VAULTRC2 & VAULTRC4/hvg4 vRNAs (putative)

Structure

• contains 1 NACHT domain
• contains 4 TEP1 N-terminal repeats
• contains 1 TROVE domain
• contains 21 WD repeats

Compartment

nucleus (probable), telomere

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• protein subunit
• WD repeat protein family

Component of

• telomerase

Database

• OMIM: https://mirror.omim.org/entry/601686
• UniProt: http://www.uniprot.org/uniprot/Q99973.html