p21-activated protein kinase-interacting protein 1; PAK1-interacting protein 1; PAK/PLC-interacting protein 1; hPIP1 (PAK1IP1, PIP1, WDR84)

Function

• negatively regulates PAK1 kinase
• binds to the N-terminus of PAK1
• inhibits specific activation of PAK1 kinase by CDC42

Structure

contains 5 WD repeats

Compartment

nuclear, nucleolar

Expression

• widely expressed
• expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen & thymus

More general terms

• WD repeat protein family
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55003
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55003
• OMIM: https://mirror.omim.org/entry/607811
• UniProt: http://www.uniprot.org/uniprot/Q9NWT1.html