tubby-related protein 4; tubby superfamily protein; tubby-like protein 4 (TULP4, KIAA1397, TUBL4, TUSP)

Function

• may be a substrate-recognition component of an SCF-like ECS complex (elongin-Cullin-SOCS-box protein complex), an E3 ubiquitin ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
• protein modification; protein ubiquitination

Structure

• the SOCS box domain mediates interaction with the elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (putative)
• belongs to the TUB family
• contains 1 SOCS box domain
• contains 3 WD repeats

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed mainly in brain, skeletal muscle, testis & kidney

More general terms

• WD repeat protein family

Additional terms

• tubby protein homolog (TUB)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56995
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56995
• UniProt: http://www.uniprot.org/uniprot/Q9NRJ4.html