tubby protein homolog (TUB)

Function

• role in signal transduction from heterotrimeric G protein-coupled receptors
• binds to membranes containing phosphatidylinositol-4,5-bisphosphate
• can bind DNA (in vitro)
• may contribute to transcriptional regulation in the nucleus
• may play role in hypothalamic regulation of body weight
• may stimulate macrophages & phagocytosis of apoptotic retinal pigment epithelium (RPE) cells
• interacts with GNAQ (putative)
• interacts with TULP1

Structure

belongs to the TUB family

Compartment

• cytoplasm (putative)
• nucleus
• secreted (putative)
• plasma membrane, cytoplasmic side (putative)
• binds phospholipid & is anchored to the plasma membrane through binding phosphatidylinositol-4,5-bisphosphate
• released upon activation of phospholipase C
• translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein Gq-alpha
• does not have a cleavable signal peptide & is secreted by a non-conventional pathway

Alternative splicing

named isoforms=2

More general terms

• cytoskeletal protein

Additional terms

• tubby-related protein 4; tubby superfamily protein; tubby-like protein 4 (TULP4, KIAA1397, TUBL4, TUSP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7275
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7275
• OMIM: https://mirror.omim.org/entry/601197
• UniProt: http://www.uniprot.org/uniprot/P50607.html