WD repeat-containing protein 12; ribosome biogenesis protein WDR12 (WDR12)

Function

• component of the PeBoW complex, required for maturation of 28S ibosomal RNA & 5.8S ribosomal RNA & formation of the 60S ribosome
• within the PeBoW complex BOP1 interacts directly with PES1 & WDR12

Structure

• belongs to the WD repeat WDR12/YTM1 family
• contains 7 WD repeats

Compartment

nucleus, nucleolus. nucleus, nucleoplasm

Expression

induced by MYC

More general terms

• WD repeat protein family

Component of

• PeBow complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55759
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55759
• UniProt: http://www.uniprot.org/uniprot/Q9GZL7.html