ribosome biogenesis protein BOP1 (block of proliferation 1 protein, BOP1, KIAA0124)

Function

• required for maturation of the 25S rRNA & 5.8S rRNA
• required for proper processing at 4 distinct sites located within the internal transcribed spacers ITS1 & ITS2 & the 3' external spacer
• role in ribosome formation that coordinates processing of spacer regions in pre-rRNA

Structure

contains 7 WD repeats

Compartment

nucleus, nucleolus

More general terms

• nuclear protein
• WD repeat protein family
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q14137.html