Pescadillo homolog (PES1)

Function

• component of the PeBoW complex
• sumoylated
• interacts with IRS1 & UBTF
• may interact with MAP1B

Structure

• belongs to the pescadillo family
• contains 1 BRCT domain

Compartment

• nucleus, nucleolus. nucleus, nucleoplasm
• appears to localize to the periphery of metaphase chromosomes during mitosis & to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli (putative)

Alternative splicing

named isoforms=2

Expression

• induced by MYC
• significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma & cervical carcinoma cells
• levels are abnormally elevated in malignant astrocytomas

More general terms

• phosphoprotein
• nuclear protein

Additional terms

• anaplastic astrocytoma (grade 3)
• glioblastoma multiforme (GBM) or astrocytoma grade IV

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23481
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23481
• OMIM: https://mirror.omim.org/entry/605819
• UniProt: http://www.uniprot.org/uniprot/O00541.html