WD repeat & FYVE domain-containing protein 1; FENS-1; phosphoinositide-binding protein 1; WD40- & FYVE domain-containing protein 1; zinc finger FYVE domain-containing protein 17 (WDFY1, KIAA1435, WDF1, ZFYVE17)

Function

• binds PtdIns3P in vitro with high specificity
• less binding to other phosphoinositides

Structure

• the FYVE-type Zn+2 finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes & penetrates bilayers
• the FYVE domain insertion into Ptdins(3)P-enriched membranes is substantially increased in acidic conditions
• contains 1 FYVE-type Zn+2 finger
• contains 7 WD repeats

Compartment

early endosomes

More general terms

• zinc finger FYVE domain-containing protein (ZFYVE)
• WD repeat protein family

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57590
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57590
• UniProt: http://www.uniprot.org/uniprot/Q8IWB7.html