protein neurobeachin; lysosomal-trafficking regulator 2; protein; BCL8 (NBEA, BCL8B, KIAA1544, LYST2)

Function

• binds to PKA2 regulatory subunits, anchors/targets them to membrane
• may anchor PKA2 to cytoskeletal &/or organelle-associated proteins

Structure

• PKA2 regulatory subunit binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the PKA2 regulatory subunit dimer (putative)
• belongs to the WD repeat neurobeachin family
• contains 1 BEACH domain
• contains 5 WD repeats

Compartment

cytoplasm, peripheral membrane

Alternative splicing

named isoforms=2

Expression

• expressed in brain > spleen, thymus, prostate, testis, ovary > heart, kidney, pancreas, skeletal muscle, intestine

More general terms

• WD repeat protein family
• human longevity protein

Additional terms

• lysosomal-trafficking regulator; Beige homolog (LYST, CHS, CHS1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26960
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26960
• OMIM: https://mirror.omim.org/entry/604889
• UniProt: http://www.uniprot.org/uniprot/Q8NFP9.html