E3 ubiquitin-protein ligase TRAF7; RING finger & WD repeat-containing protein 1; RING finger protein 119; TNF receptor-associated factor 7 (TRAF7, RFWD1, RNF119)

Function

• E3 ubiquitin ligase
• capable of auto-ubiquitination, following phosphorylation by MAP3K3
• potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 & DDIT3 transcriptional regulators
• induces apoptosis when overexpressed
• protein modification; protein ubiquitination
• phosphorylated by MAP3K3
• ubiquitinates itself upon phosphorylation
• enhances kinase activity of MAP3K3

Structure

• homodimer
• belongs to the WD repeat TRAF7 family
• contains 1 RING-type Zn+2 finger
• contains 1 TRAF-type Zn+2 finger
• contains 7 WD repeats

Compartment

• cytoplasmic vesicle
• colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed
• high expresion in skeletal muscle, heart, colon, spleen, kidney, liver & placenta

More general terms

• E3 ubiquitin ligase
• WD repeat protein family
• ring finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84231
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84231
• OMIM: https://mirror.omim.org/entry/606692
• UniProt: http://www.uniprot.org/uniprot/Q6Q0C0.html