Fizzy-related protein homolog; Fzr; Cdh1/Hct1 homolog; hCDH1; CDC20-like protein 1 (FZR1, CDH1, FYR, FZR, KIAA1242)

Function

• regulates ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) & may confer substrate specificity upon the complex
• the APC/C-Cdh1 dimeric complex is activated during anaphase & telophase & remains active in degrading substrates until onset of the next S phase
• protein modification; protein ubiquitination
• phosphorylated during mitosis, probably by maturation promoting factor (MPF)
• the unphosphorylated form interacts with APC/C during mitosis
• interacts with NINL

Structure

• belongs to the WD repeat CDC20/Fizzy family
• contains 7 WD repeats

Compartment

• isoform 2: nucleus
• isoform 3: cytoplasm

Alternative splicing

named isoforms=3

Expression

• isoform 2 is expressed at high levels in heart, liver, spleen & some cancer cell lines
• isoform 3 is expressed only at low levels in these tissues

More general terms

• transcription factor (TF)
• WD repeat protein family
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51343
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51343
• OMIM: https://mirror.omim.org/entry/603619
• UniProt: http://www.uniprot.org/uniprot/Q9UM11.html