ninein-like protein (NLP, NINL, KIAA0980)

Function

• role in microtubule organization in interphase cells
• overexpression induces the fragmentation of Golgi, & causes lysosomes to disperse toward the cell periphery, also interferes with mitotic spindle assembly
• interacts with gamma-tubulin
• during centrosome maturation, PLK1 directly phosphorylates NLP resulting in its release into the cytoplasm phosphorylation by PLK1 disrupts its centrosome association

Structure

contains 4 EF-hand domains

Compartment

• centrosome, cytoplasm
• in interphase cells, NLP is transported to the centrosomes by the dynein-dynactin motor complex
• during centrosome maturation, PLK1 directly phosphorylates NLP resulting in its release into the cytoplasm

More general terms

• Ca+2 binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y2I6.html