WD repeat-containing protein 4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 (WDR4)

Function

• required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
• forms a complex with METTL1 (tRNA guanine-N7-methyltransferase)
• in the complex, it is required to stabilize & induce conformational change of the catalytic subunit
• tRNA modification; N(7)-methylguanine-tRNA biosynthesis

Structure

• belongs to the WD repeat TRM82 family
• contains 4 WD repeats

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• WD repeat protein family
• nuclear protein
• phosphoprotein
• protein subunit

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10785
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10785
• OMIM: https://mirror.omim.org/entry/605924
• UniProt: http://www.uniprot.org/uniprot/P57081.html