tRNA (guanine-N(7)-)-methyltransferase (tRNA(m7G46)-methyltransferase, methyltransferase-like protein 1, METTL1, C12orf1)

Function

• catalyzes the formation of 7-N-methylguanine at position 46 (m7G46) in tRNA
• forms a complex with WDR4

S-adenosyl-L-methionine + tRNA

<-->

S-adenosyl-L-homocysteine + tRNA containing 7-N-methylguanine

Structure

• belongs to the methyltransferase superfamily, TrmB family

Expression

ubiquitous

More general terms

• methyltransferase

Additional terms

• WD repeat-containing protein 4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 (WDR4)

Database

• OMIM: https://mirror.omim.org/entry/604466
• UniProt: http://www.uniprot.org/uniprot/Q9UBP6.html