dual-specificity tyrosine-phosphorylation regulated kinase 1A (protein kinase minibrain homolog, MNBH, HP86, dual specificity YAK1-related kinase, Dyrk1A)
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Function
- role in signaling pathway regulating nuclear functions of cell proliferaration
- phosphorylates Ser, Thr & Tyr
- phosphorylates microtubule associated protein tau at Thr212
- autophosphoryates on TYR
- interacts with RANBP9
Compartment
Alternative splicing
named isoforms=5
Expression
- ubiquitous
- highest levels in skeletal muscle, testis, fetal lung, fetal kidney
- expressed in the developing central nervous system
Pathology
- overexpressed 1.5-fold in fetal Down syndrome brain
- increased expression in cytoplasm & nuclei of scattered neurons of the neocortex, entorhinal cortex, hippocampus in Alzheimer's disease, Pick's disease & Down syndrome
- found in fractions enriched in phosphorylated tau[2]
- tau phosphorylation at Thr212 appears NOT to be the mechanism
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q13627.html
- ↑ 2.0 2.1 Ferrer I, Barrachina M, Puig B, Martinez de Lagran M, Marti E, Avila J, Dierssen M. Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Neurobiol Dis. 2005 Nov;20(2):392-400. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16242644