forkhead box protein O1A; forkhead in rhabdomyosarcoma; FKHR protein (FOXO1A)
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Function
- transcription factor
- phosphorylation by AKT1 is induced by insulin IGF1 rapidly induces phosphorylation of Thr-24, Ser-256 & Ser-319 phosphorylation of Ser-256 decreases DNA-binding activity & promotes phosphorylation of Thr-24, & Ser-319, which leads to nuclear exclusion & loss of function
- LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity[4]
Structure
contains 1 fork-head DNA-binding domain
Compartment
Expression
Pathology
- chromosomal translocation t(2;13)(q35;q14) involving FOXO1A with PAX3 & t(1;13)(p36;q14) with PAX7 are a cause of alveolar rhabdomyosarcoma resulting protein is a transcriptional activator
Polymorphism
More general terms
References
- ↑ OMIM https://mirror.omim.org/entry/136533
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2308
- ↑ UniProt http://www.uniprot.org/uniprot/Q12778.html
- ↑ 4.0 4.1 Nakae J, Cao Y, Daitoku H, Fukamizu A, Ogawa W, Yano Y, Hayashi Y. The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. J Clin Invest. 2006 Sep;116(9):2473-83. Epub 2006 Aug 17. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16917544
- ↑ 5.0 5.1 Li Y et al Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum Mol Genet. 2009 Dec 15;18(24):4897-904. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19793722