alveolar rhabdomyosarcoma (rhabdomyosarcoma-2)

Immunophenotype

see rhabdomyosarcoma CD99 + ~10% of cases

Genetics

• associated with chromosomal translocations
• t(2;13)(q35;q14) with fusion of PAX3 & FKHR genes
• t(1;13)(p36;;q14) with fusion of PAX7 & FKHR (FOXO1A) genes

Clinical manifestations

Infrequently metastasis to breast in female patients

More general terms

• rhabdomyosarcoma (Sarcoma Botryoides)

Additional terms

• chromosomal translocation t(2;13)(q35;q14)
• chromosomal translocation t1p36:13q14

Database

• OMIM: https://mirror.omim.org/entry/268220