80 kD nuclear cap binding protein (NCBP 80 kD subunit, nuclear cap-binding protein subunit 1, CBP80, NCBP1, NCBP)

Function

• role in mediating U snRNA export from the nucleus
• binds to 5'capped mRNA
• found in a U snRNA export complex with RNUXA/PHAX, CBP20, CBP80, RAN, XPO1 & m7G-capped RNA
• interaction with RNUXA/PHAX (putative)
• heterodimer with NCBP2
• part of the exon junction complex

Structure

• belongs to the NCBP1 family
• contains 1 MIF4G domain

Compartment

nucleus

More general terms

• protein subunit
• phosphoprotein

Additional terms

• eukaryotic translation initiation factor 4E (eIF4E, mRNA cap-binding protein)

Component of

• exon junction complex (EJC)
• nuclear mRNA cap-binding protein

Database

• OMIM: https://mirror.omim.org/entry/600469
• UniProt: http://www.uniprot.org/uniprot/Q09161.html