nuclear cap binding protein subunit 2 (20 kD nuclear cap binding protein, NCBP 20 kD subunit, CBP20, NCBP interacting protein 1, NIP1)

Function

• involved in mediating U snRNA export from the nucleus
• binds to 5'capped mRNA
• heterodimer with NCBP1.
• component of nuclear mRNA cap-binding protein
• component of exon junction complex
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the RRM NCBP2 family
• contains 1 RRM domain (RNA recognition motif)

Compartment

nucleus

More general terms

• protein subunit
• phosphoprotein

Component of

• exon junction complex (EJC)
• nuclear mRNA cap-binding protein

Database

• OMIM: https://mirror.omim.org/entry/605133
• UniProt: http://www.uniprot.org/uniprot/P52298.html