nucleoporin-like 2 (NLP-1, hCG1, NUP42 homolog, NUPL2, CG1)

Function

• export of mRNAs containing polyA tails from the nucleus into cytoplasm
• component of the nuclear pore complex
• interacts with nuclear export protein NXF1
• interacts with GLE1L
  • forms heterotrimer with NUP155 & GLE1L in vitro

Compartment

• nucleus, nuclear pore complex, cytoplasmic side
• excluded from the nucleolus

Alternative splicing

named isoforms=3

Expression

ubiquitously expressed

Pathology

• may participate in the docking of HIV1 viral Vpr at the nuclear envelope
• interacts with the HIV-1 virus proteins Rev & Vpr

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/O15504.html