serologically defined colon cancer antigen 1; nuclear export mediator factor NEMF; antigen NY-CO-1 (NEMF SDCCAG1)

Function

• role in nuclear export
• interacts (via its N-terminus) with XPO1 (putative)

Structure

• the N-terminal domain contains a nuclear export signal
• the C-terminal domain may interact with cargo proteins
• belongs to the NEMF family

Compartment

nucleus (putative)

Alternative splicing

named isoforms=5

Expression

• expressed in brain, heart, liver, lung, spleen, & skeletal muscle
• expressed at lower levels in stomach & testis

Pathology

• inactive in several lung cancer cell lines
  • active in normal lung tissue

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9147
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9147
• OMIM: https://mirror.omim.org/entry/608378
• UniProt: http://www.uniprot.org/uniprot/O60524.html