myosin regulatory light polypeptide 9; myosin regulatory light chain 9; myosin regulatory light chain MRLC1; myosin regulatory light chain 2, smooth muscle isoform; myosin RLC; MLC-2C; LC20 (MYL9, MLC2, MRLC1, MYRL2)

Function

• myosin regulatory light chain
• role in regulation of both smooth muscle & nonmuscle cell contractile activity via its phosphorylation
• implicated in cytokinesis, receptor capping, & cell locomotion
• phosphorylation increases the actin-activated myosin ATPase activity, thus regulates the contractile activity
• required to generate the driving force in the migration of cells, but not necessary for localization of myosin-2 at the leading edge (putative)
• binds Ca+2

Structure

contains 3 EF-hand domains

Expression

• smooth muscle tissues & in some, but not all, nonmuscle cells

More general terms

• myosin regulatory light chain (MRLC)

Additional terms

• myosin

Database

• UniProt: http://www.uniprot.org/uniprot/P24844.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10398
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10398
• OMIM: https://mirror.omim.org/entry/609905